Product Name :
NM23 Mouse Monoclonal Antibody [12A1]

Predicted band size :
17 kDa

Observed band size :
17/19 kDa

Synonyms:
AWD antibody AWD, drosophila, homolog of antibody GAAD antibody Granzyme A activated DNase antibody Granzyme A-activated DNase antibody GZMA activated DNase antibody Metastasis inhibition factor NM23 antibody NB antibody NBS antibody NDK A antibody 展开

Function :
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3′-5′ exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.Buy2621932-42-9 During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3′ end to enhance DNA damage and prevent DNA end reannealing and rapid repair. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.

Antibody Type:
Mouse Monoclonal Antibody

Immunogen :
Synthetic peptide within Human NM23 aa 78-126 / 152.

Species reactivity:
Human, Mouse, Rat

Verify application:
WB, IF-Cell, IHC-P, FC

Coupling :
unconjugated

Clone number:
12A1

RRID:
AB_3068843

Form :
Liquid

Concentration :
2ug/ul

Storage instructions:
Store at +4℃ after thawing.387859-70-3 site Aliquot store at -20℃.PMID:33599243 Avoid repeated freeze / thaw cycles.

Storage buffer solution:
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Subtype:
IgG1

Purification method :
Protein G affinity purified.

ELTSA :

Molecular weight :
Predicted band size: 17 kDa

Positive control :
HeLa cell lysate, A431 cell lysate, A549 cell lysate, MCF7 cell lysate, Caco-2 cell lysate, PC-3M cell lysate, HepG2 cell lysate, NIH/3T3 cell lysate, C6 cell lysate, rat brain tissue lysate, human breast cancer tissue, human liver cancer tissue, human thyroid gland tissue, MCF7.