Pathol. 2005; 18:1542?549. [PubMed: 16056244] 38. Asano N, Oshiro A, Matsuo K, et al. Prognostic significance of T-cell or cytotoxic molecules phenotype in classical Hodgkin’s lymphoma: a clinicopathologic study. J Clin Oncol. 2006; 24:4626?633. [PubMed: 16954517] 39. Takahashi T, Maruyama R, Mishima S, et al. Compact bowel perforation caused by Epstein-Barr virus-associated B cell lymphoma in a patient with angioimmunoblastic T-cell lymphoma. J Clin Exp Hematop. 2010; 50:59?three. [PubMed: 20505277]NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptAm J Surg Pathol. Author manuscript; readily available in PMC 2014 June 01.Nicolae et al.PageNIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptFigure 1.Angioimmunoblastic T-cell lymphoma with EBV-positive Hodgkin-Reed Sternberg-like cells. A. A big multinucleate cell is observed in a background of atypical lymphoid cells. B. CD3 highlights the cytologic atypia inside the T-cells and presence of rosettes about HodgkinReed Sternberg-like cell (upper left corner). C. T-cell rosettes are good for CD10. D. Expanded CD21-positive follicular dendritic meshworks surround multinucleated cells (upper left corner). The Hodgkin-Reed Sternberg-like cells show sturdy membrane positivity for CD30 (E), CD15 (F), weak nuclear staining for PAX5 (G) and EBER positivity (H).Am J Surg Pathol. Author manuscript; accessible in PMC 2014 June 01.Nicolae et al.PageNIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptFigure 2.Angioimmunoblastic T-cell lymphoma with EBV-negative Hodgkin-Reed Sternberg-like cells (cases 1 and 2). A. Effaced lymph node with paracortical expansion and preserved and dilated peripheral cortical sinus. B. Polymorphous infiltrate composed of pleomorphic cells with uni or multilobated nuclei and prominent nucleoli, resembling Hodgkin-Reed Sternberg cells admixed with medium sized atypical lymphocytes. C. Dilated subcapsular sinus with atypical Hodgkin-Reed Sternberg-like cells (detail in inset) D.Methyl 4-bromopyrimidine-2-carboxylate In stock Hodgkin-Reed Sternberg-like cells (detail in inset) are embedded in expanded CD21-positive follicular dendritic cell meshworks.1198605-51-4 custom synthesis They’re constructive for CD30 (E), CD15 (F), variably good for CD20 (G inset), weakly constructive for PAX5 (H), but adverse for EBER (I).PMID:23600560 G. CD20 stain shows alsoAm J Surg Pathol. Author manuscript; accessible in PMC 2014 June 01.Nicolae et al.Pagemarginalized B-cell areas in the far cortex. The Hodgkin-Reed Sternberg-like cells are rosetted by neoplastic T-cells good for CD3 (J), PD-1 (K), CD10 (L). M. HRS-cells are unfavorable for Bcl-6, which stains some background T-cells. (A, B, C, F, G, H, K, L M ?case 1; D, E I, J ase 2)NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptAm J Surg Pathol. Author manuscript; obtainable in PMC 2014 June 01.Nicolae et al.PageNIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptFigure 3.Peripheral T-cell lymphoma not otherwise specified, follicular variant, with Hodgkin-Reed Sternberg-like cells, EBV adverse (case 4 and 5). A. The nodal architecture is altered by several irregular, disrupted follicles. B. Pale cluster of small-medium sized T-lymphocytes within the substantial nodule. C. Pleomorphic mono or binucleate Hodgkin-Reed Sternberg-like cells are noticed amidst atypical T-cells (detail in inset). Hodgkin-Reed Sternberg-like cells strongly express CD30 (Da), CD15 (Db), weakly CD20 (Dc) and are adverse for EBER (Dd). They’re also weak optimistic.